Enzymatic serum/plasma Ethylene Glycol Test Reagent (C504-0A - Quantitative)
Ethylene Glycol is a key component in most antifreeze products. The ingestion of ethylene glycol can quickly poison an individual or an animal and lead to irreversible liver and kidney damage if poisoning is not determined to have occurred and is not quickly treated. If ethylene glycol is shown to be present in a blood sample, treatment is relatively simple. Catachem has developed an accurate quantitative test (C504-0A) that determines ethylene glycol levels. Values obtained on Catachem's quantitative test reagent compare closely to values obtained on GC/MS methods (Am.J.Clin.Pathol. 2011, 136:165-6). Catachem's product has been designed to effectively eliminate interferences from propylene glycol, a secondary component in some antifreeze products and also a chemical used as an additive in some veterinary drugs and foodstuffs.
NOTE: Diethylene Glycol has no significant effect on the accuracy of this Ethylene Glycol procedure up to a concentration of 100 mM nor does the use of Fomepizole, the pharmaceutical antidote to ethylene glycol poisoning.
Ethylene Glycol is a key component in most antifreeze products. The ingestion of ethylene glycol can quickly poison an individual or an animal and lead to irreversible liver and kidney damage if poisoning is not determined to have occurred and is not quickly treated. If ethylene glycol is shown to be present in a blood sample, treatment is relatively simple. Catachem has developed an accurate quantitative test (C504-0A) that determines ethylene glycol levels. Values obtained on Catachem's quantitative test reagent compare closely to values obtained on GC/MS methods (Am.J.Clin.Pathol. 2011, 136:165-6). Catachem's product has been designed to effectively eliminate interferences from propylene glycol, a secondary component in some antifreeze products and also a chemical used as an additive in some veterinary drugs and foodstuffs.
NOTE: Diethylene Glycol has no significant effect on the accuracy of this Ethylene Glycol procedure up to a concentration of 100 mM nor does the use of Fomepizole, the pharmaceutical antidote to ethylene glycol poisoning.
FasTox Ethylene Glycol Test Reagent (C504-0C)
Catachem’s FasTox Ethylene Glycol Test (C504-0C) is designed for laboratories that only encounter the occasional patient sample that may contain ethylene glycol. The FasTox test uses Catachem’s quantitative ethylene glycol assay technology and packages this into a three test pack that delivers a semi quantitative result using a simple spectrophotometer. Depending on how the test is read, it may also be used as a general glycol screen. If glycol is present it can be determined whether this is most likely ethylene glycol or not. Each test is self-contained and comes with its own reagent and controls which are used only once and then discarded. Used this way, each test is essentially self-calibrating. The “3 test” kits have a shelf life of 18 months to reduce any possible waste. Accuracy and specificity of the FasTox ethylene glycol test has been independently verified in a study against GC/Mass. Spec. data. In this study 21 various samples were tested using both methods and 100% correlation at the decision level for each test was obtained.
Plasma Free Haemoglobin (C464-0A, C462-0A)
Normal plasma should not contain free haemoglobin. If blood is taken from an individual or an animal and is processed or manipulated in any way (dialysis, heart pump etc.) or if the patient has suffered intravascular hemolysis, caused by a number of disease states, damage to the red blood cells will be evident as haemoglobin is released into the plasma. Catachem has developed an extremely sensitive assay to accurately measure very small amounts of haemoglobin that may be present in a plasma sample. The method can be run on most clinical chemistry analyzers unlike similar methods in the past. The method is sensitive and accurate enough to measure heamoglobin at levels as low as 2 mg/dL (1.2 µmol/L). The method demonstrates linearity on most analyzers to 100 mg/dL (60 µmol/L).
CataKlear (CLR-525)
Highly lipaemic serum samples are difficult to analyze accurately due to lipaemic interference. Catachem's CataKlear reagent is designed to eliminate most of this interference by releasing, then precipitating lipids and attaching them to a carefully size mixture of silicone oxide nano particles. After centrifugation these lipid-nanoparticle complexes are forced to the bottom of the centrifuge tube leaving a lipid-free layer of serum which is easily decanted for assay. Although some analytes are affected by this procedure and therefore cannot be accurately analyzed (i.e. calcium, C-reactive protein and a few others), the majority of analytes are not affected. This allows the clinician the ability to report patient values that would be otherwise un-reportable.
*For Product/Methodology Sheets and MSDS Sheets, please visit our Downloads page. *
Catachem’s FasTox Ethylene Glycol Test (C504-0C) is designed for laboratories that only encounter the occasional patient sample that may contain ethylene glycol. The FasTox test uses Catachem’s quantitative ethylene glycol assay technology and packages this into a three test pack that delivers a semi quantitative result using a simple spectrophotometer. Depending on how the test is read, it may also be used as a general glycol screen. If glycol is present it can be determined whether this is most likely ethylene glycol or not. Each test is self-contained and comes with its own reagent and controls which are used only once and then discarded. Used this way, each test is essentially self-calibrating. The “3 test” kits have a shelf life of 18 months to reduce any possible waste. Accuracy and specificity of the FasTox ethylene glycol test has been independently verified in a study against GC/Mass. Spec. data. In this study 21 various samples were tested using both methods and 100% correlation at the decision level for each test was obtained.
Plasma Free Haemoglobin (C464-0A, C462-0A)
Normal plasma should not contain free haemoglobin. If blood is taken from an individual or an animal and is processed or manipulated in any way (dialysis, heart pump etc.) or if the patient has suffered intravascular hemolysis, caused by a number of disease states, damage to the red blood cells will be evident as haemoglobin is released into the plasma. Catachem has developed an extremely sensitive assay to accurately measure very small amounts of haemoglobin that may be present in a plasma sample. The method can be run on most clinical chemistry analyzers unlike similar methods in the past. The method is sensitive and accurate enough to measure heamoglobin at levels as low as 2 mg/dL (1.2 µmol/L). The method demonstrates linearity on most analyzers to 100 mg/dL (60 µmol/L).
CataKlear (CLR-525)
Highly lipaemic serum samples are difficult to analyze accurately due to lipaemic interference. Catachem's CataKlear reagent is designed to eliminate most of this interference by releasing, then precipitating lipids and attaching them to a carefully size mixture of silicone oxide nano particles. After centrifugation these lipid-nanoparticle complexes are forced to the bottom of the centrifuge tube leaving a lipid-free layer of serum which is easily decanted for assay. Although some analytes are affected by this procedure and therefore cannot be accurately analyzed (i.e. calcium, C-reactive protein and a few others), the majority of analytes are not affected. This allows the clinician the ability to report patient values that would be otherwise un-reportable.
*For Product/Methodology Sheets and MSDS Sheets, please visit our Downloads page. *